Sicily, a mitochondrial chaperone required for neuronal integrity
- Shinya Yamamoto
- Mar 18, 2013
- 1 min read
Through a forward genetic screen we performed on the Drosophila X-chromosome, we found that loss of sicily cause photoreceptor degeneration. We further found that this gene encodes a mitochondria chaperone that stabilizes Complex I subunits, and rare variants in its human homolog causes Leigh syndrome.
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