top of page
  • Writer's pictureShinya Yamamoto

Sicily, a mitochondrial chaperone required for neuronal integrity

Through a forward genetic screen we performed on the Drosophila X-chromosome, we found that loss of sicily cause photoreceptor degeneration. We further found that this gene encodes a mitochondria chaperone that stabilizes Complex I subunits, and rare variants in its human homolog causes Leigh syndrome.


1 view

Kommentit


bottom of page