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Sicily, a mitochondrial chaperone required for neuronal integrity

  • Writer: Shinya Yamamoto
    Shinya Yamamoto
  • Mar 18, 2013
  • 1 min read

Through a forward genetic screen we performed on the Drosophila X-chromosome, we found that loss of sicily cause photoreceptor degeneration. We further found that this gene encodes a mitochondria chaperone that stabilizes Complex I subunits, and rare variants in its human homolog causes Leigh syndrome.


 
 
 

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