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  • Writer's pictureShinya Yamamoto

Sicily, a mitochondrial chaperone required for neuronal integrity

Through a forward genetic screen we performed on the Drosophila X-chromosome, we found that loss of sicily cause photoreceptor degeneration. We further found that this gene encodes a mitochondria chaperone that stabilizes Complex I subunits, and rare variants in its human homolog causes Leigh syndrome.

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